Open AccessSeizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis
Author(s) -
Kar Wah Fuah,
Christopher Thiam Seong Lim,
Daniel Pang,
Jin Shyan Wong
Publication year - 2018
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.225177
Subject(s) - tranexamic acid , medicine , antifibrinolytic , hemostasis , dialysis , hemodialysis , kidney disease , anesthesia , intensive care medicine , surgery , blood loss
Tranexamic acid (TXA) is an antifibrinolytic agent commonly used to achieve hemostasis. However, there have been a few case reports suggesting that high-dose intravenous TXA has epileptogenic property. In patients with renal impairment, even administering the usual recommended dose of TXA can induce seizure episodes. We present here a patient on hemodialysis who developed seizures after receiving two doses of TXA over 5 h period.