Open AccessFamilial hemolytic uremic syndrome with occurrence in the postpartum period
Author(s) -
Myftar Barbullushi,
Alma Idrizi,
Goce Spasovski
Publication year - 2017
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.220859
Subject(s) - medicine , period (music) , postpartum period , pediatrics , atypical hemolytic uremic syndrome , pregnancy , genetics , immunology , antibody , complement system , biology , physics , acoustics
The hemolytic uremic syndrome (HUS) is a heterogeneous group of similar entities characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure (ARF) and is an important cause of ARF in childhood. Mutations have been reported in the complement regulatory protein factor H in both sporadic and familial HUS and have been identified in 10-20% of cases. Inherited HUS is unusual. We report the occurrence of HUS in two siblings after delivery, complicated with ARF and with a good outcome.