Open AccessPrimary Sjögren’s syndrome complicated by anti-neutrophil cytoplasmic antibody-mediated crescentic glomerulonephritis
Author(s) -
I. Ben Ghorbel,
Nabil Belfeki,
T. Ben Salem,
M.H. Houman
Publication year - 2017
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.215153
Subject(s) - medicine , prednisone , glomerulonephritis , cyclophosphamide , nephritis , anti neutrophil cytoplasmic antibody , pathology , antibody , kidney , immunology , vasculitis , gastroenterology , chemotherapy , disease
Ocular and oral dryness are the hallmark of Sjögren’s syndrome (SS). However, SS can be associated with a variety of complications, affecting organs such as the liver, kidneys, lungs, muscle, and nervous system. Renal involvement has been usually in the form of tubulointerstitial nephritis. However, glomerulonephritis is rare in primary SS. We report three clinical cases of SS with anti-neutrophil cytoplasmic antibody-mediated crescentic glomerulo-nephritis treated with prednisone and cyclophosphamide, with favorable outcome