Open AccessRenal transplantation in HIV-positive patients – No more a scare!
Author(s) -
Mahesh Eswarappa,
Manns Manohar John,
Gurudev Channabasappa Konana,
Rakesh Madhyastha Parampalli,
Sujeeth Reddy Bande,
Sarita Suryadevara
Publication year - 2017
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.215132
Subject(s) - contraindication , medicine , transplantation , nephropathy , exacerbation , kidney transplantation , kidney disease , intensive care medicine , immunology , disease , pathology , diabetes mellitus , alternative medicine , endocrinology
Human immunodeficiency virus (HIV) infection has posed as a major global health epidemic for almost three decades. With the advent of highly active antiretroviral therapy in 1996 and the application of prophylaxis and management of opportunistic infections, acquired immunodeficiency syndrome mortality has decreased markedly. The most aggressive HIV-related renal disease is end-stage renal disease due to HIV-associated nephropathy. Presence of HIV infection used to be viewed as a contraindication to renal transplantation for multiple reasons; concerns for exacerbation of an already immunocompromised state by administration of additional immunosuppressants; the use of a limited supply of donor organs with unknown long-term outcomes. Multiple studies have reported promising outcomes at three to five years after kidney transplantations in patients treated with highly active antiretroviral therapy, and HIV is no longer a contraindication for renal transplant. Hence, we present eight HIV-positive patients who received live-related renal transplantation at our center and their follow-up