Open AccessAn overlap of granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis
Author(s) -
Sujit Surendran,
Chandramohan Gundappa,
Arun Gandhi,
Abraham Kurien,
Edwin Fernando
Publication year - 2017
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.206450
Subject(s) - granulomatosis with polyangiitis , medicine , eosinophilic , anti neutrophil cytoplasmic antibody , pathology , microscopic polyangiitis , rapidly progressive glomerulonephritis , eosinophilic pneumonia , diffuse alveolar hemorrhage , vasculitis , cyclophosphamide , necrotizing vasculitis , methylprednisolone , respiratory disease , chemotherapy , lung , disease
We present a case report of overlap of granulomatosis with polyangiitis (GPA; formerly known as Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome). We report a 45-year-old female who presented with rapidly progressive renal failure associated with fever, polyarthralgia, and respiratory symptoms with cytoplasmic antineutrophilic cytoplasmic antibody (ANCA) and proteinase (PR-3) antigen positivity. Computerized tomography scan of the chest showed diffuse alveolar hemorrhage with renal biopsy revealing pauci-immune necrotizing crescentic glomerulonephritis with intense eosinophilic infiltration suggestive of eosinophilic GPA (EGPA). Our patient had ANCA-associated vasculitis (AAV) with features suggestive of both GPA and EGPA. She was treated with methylprednisolone and cyclophosphamide and attained remission after 2 weeks of therapy. This is a rare report of a patient with AAV having features of both EGPA and GPA.