Open AccessAssociations between clinical characteristics and angiotensin-converting enzyme gene insertion/deletion polymorphism in Moroccan population with Type-2 diabetic nephropathy
Author(s) -
Maria Mansouri,
Amal Zniber,
Lamia Boualla,
Ghizlane El Badaoui,
Mariam Benkacem,
Kaoutar Rifai,
A. Chraïbi,
L. Benamar,
Abdelaziz Sefiani,
R. Bayahia
Publication year - 2017
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.202792
Subject(s) - diabetic nephropathy , medicine , genotype , angiotensin converting enzyme , allele , nephropathy , type 2 diabetes mellitus , diabetes mellitus , population , gastroenterology , allele frequency , gene polymorphism , polymorphism (computer science) , endocrinology , polymerase chain reaction , genetics , gene , biology , blood pressure , environmental health
Diabetic nephropathy (DN) is one of the severe complications of Type-2 diabetes mellitus (T2DM) and a major cause of end-stage renal disease in these patients. Results from published studies on the relationship between angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) gene polymorphism and patients with DN are still conflicting. We compared the clinical characteristics and the genotype frequencies of ACE polymorphism in 130 T2DM Moroccan patients with DN and 85 T2DM Moroccan patients without DN (controls) using specific primers in a polymerase chain reaction. The degenerative complications of diabetes were significantly higher in the group with nephropathy. The distribution of the I/D genotypes was in Hardy-Weinberg equilibrium. The D allele was the most frequent allele in the Moroccan population in both groups studied (P = 0.68), however, there was no significant difference between the genotypes in T2DM patients with or without DN (P = 0.78). The ACE gene I/D polymorphism was not associated with an increased risk of DN in the Moroccan population.