Open AccessRenal manifestations of human brucellosis: First report of minimal change disease
Author(s) -
Nikolaos Sabanis,
Eleni Gavriilaki,
Eleni Paschou,
Eleni Tsotsiou,
Asterios Kalaitzoglou,
Christos Kavlakoudis,
Sotirios Vasileiou
Publication year - 2016
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.182413
Subject(s) - medicine , brucellosis , minimal change disease , doxycycline , prednisone , rifampicin , renal biopsy , nephrotic syndrome , disease , surgery , pediatrics , gastroenterology , immunology , glomerulonephritis , biopsy , antibiotics , pathology , kidney , tuberculosis , focal segmental glomerulosclerosis , microbiology and biotechnology , biology
Human brucellosis is considered a great example of the complexity of clinical manifestations possibly affecting multiple organs or systems. Renal manifestations of human brucellosis have been documented in few case reports and one case series. Herein, we present a case of Nephrotic syndrome (NS) due to minimal change disease in the course of acute brucellosis. A 53-year-old male farmer was admitted to our department with acute brucellosis and NS. Renal biopsy revealed minimal change disease. Combined treatment with prednisone (1 mg/kg), rifampicin (600 mg/day), and doxycycline (200 mg/day) was initiated. Complete remission of NS was achieved at the end of the fourth week. One year later, the patient remained in complete remission of NS without any sign of relapse of brucellosis.