Open AccessQuadriparesis due to Gitelman′s syndrome diagnosed with thiazide diuretic test response
Author(s) -
S. Mukhopadhyay,
Swapan Kumar Jana,
Apratim Chatterjee,
Manoj Roy,
Anindya Sarkar,
Jotideb Mukhopadhyay
Publication year - 2016
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.178584
Subject(s) - hypocalciuria , gitelman syndrome , hypomagnesemia , medicine , thiazide , distal convoluted tubule , hypokalemia , endocrinology , tetany , tubulopathy , diuretic , reabsorption , kidney , chemistry , magnesium , organic chemistry
Gitelman's syndrome is characterized by hypocalciuria, severe hypomagnesemia, and prominent muscular involvements such as fatigue, weakness, cramps, and tetany. It is due to mutations in the thiazide sensitive NaCl co-transporter in the distal convoluted tubule. The administration of thiazide diuretics may induce a subnormal increase of urinary Cl(-) excretion in patients with Gitelman's syndrome, consistent with the hypothesis that less than normal Cl(-) is reabsorbed by the thiazide-inhibitable transporter in Gitelman's syndrome. Thus, we report a case of Gitelman's syndrome presenting with quadriparesis diagnosed by using thiazide clearance test.