Open AccessChromophobe renal cell carcinoma occurring in the renal allograft of a transplant recipient presenting with weight loss
Author(s) -
Mohammed Mahdi Althaf,
Mohammed Al-Sunaid,
Mohamed Said Abdelsalam,
Lutfi Alkorbi,
Turki Al-Hussain,
Mohammed Dababo,
Naveed Ul Haq
Publication year - 2016
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.174165
Subject(s) - medicine , renal cell carcinoma , asymptomatic , nephrectomy , chromophobe cell , immunosuppression , transplantation , population , kidney , weight loss , kidney transplantation , urology , pathology , clear cell , obesity , environmental health
The incidence of renal cell carcinomas (RCCs) in renal transplant recipients is reported as 1.1-1.5% in the native kidneys and 0.22-0.25% in the renal allograft. There are no data to support routine surveillance for tumors in transplant recipients. Most reported cases of RCCs occurring in renal allografts were incidental findings in asymptomatic patients. Herein, we report the second case of lone chromophobe RCC (ChRCC) of the renal allograft presenting with weight loss. Loss of weight is a presenting symptom in one-third of ChRCCs occurring in the native kidneys in the general population. Based on the age of the patient, R.E.N.A.L nephrometry score of the tumor and the lack of data on the prognosis of this histological subtype in a climate of long-term immunosuppression, we elected for radical nephrectomy. We suggest that RCCs should be considered in the differential diagnosis of a transplant recipient presenting with weight loss even in the absence of localizing symptoms or signs.