Coexistence of sickle cell nephropathy and lupus nephritis in a Sudanese child | Zendy

Ahmed B. Idris | Zendy; Ala Abdulgayoom | Zendy; Eman Mudawi | Zendy; AM El Hassan | Zendy; Elwaleed M. Elamin | Zendy; LamyaaAhmed Mohamed El Hassan | Zendy

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Coexistence of sickle cell nephropathy and lupus nephritis in a Sudanese child

Author(s) -

Ahmed B. Idris,

Ala Abdulgayoom,

Eman Mudawi,

AM El Hassan,

Elwaleed M. Elamin,

LamyaaAhmed Mohamed El Hassan

Publication year - 2015

Publication title -

saudi journal of kidney diseases and transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 30

eISSN - 2320-3838

pISSN - 1319-2442

DOI - 10.4103/1319-2442.157397

Subject(s) - medicine , lupus nephritis , nephropathy , nephrotic syndrome , renal biopsy , disease , nephritis , immunology , systemic lupus erythematosus , hemolysis , biopsy , pediatrics , endocrinology , diabetes mellitus

In spite of the wide distribution of sickle cell disease (SCD) in Africa, an association with systemic lupus erythromatosis (SLE) is seldom reported. This may be due to the poor association between the two diseases or the high prevalence of missed cases. Progressive renal injury is prominent in both SCD and SLE. In this communication, we are presenting a case of an 11-year-old male who presented with sickle cell nephropathy that manifested as nephrotic syndrome with no response to conservative therapy, alongside unexplained massive hemolysis. His renal biopsy proved SLE superimposed on sickle cell nephropathy. We are stressing the importance of considering alternate disease processes in patients with SCD when symptoms change or when there is an atypical clinical course.

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