Open AccessCoexistence of sickle cell nephropathy and lupus nephritis in a Sudanese child
Author(s) -
Ahmed Idris,
Ala Abdulgayoom,
Eman Mudawi,
Amro B. Hassan,
Elwaleed Mohamed Elamin,
Lamyaa Ahmed Mohamed El Hassan
Publication year - 2015
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.157397
Subject(s) - medicine , lupus nephritis , nephropathy , nephrotic syndrome , renal biopsy , disease , nephritis , immunology , systemic lupus erythematosus , hemolysis , biopsy , pediatrics , endocrinology , diabetes mellitus
In spite of the wide distribution of sickle cell disease (SCD) in Africa, an association with systemic lupus erythromatosis (SLE) is seldom reported. This may be due to the poor association between the two diseases or the high prevalence of missed cases. Progressive renal injury is prominent in both SCD and SLE. In this communication, we are presenting a case of an 11-year-old male who presented with sickle cell nephropathy that manifested as nephrotic syndrome with no response to conservative therapy, alongside unexplained massive hemolysis. His renal biopsy proved SLE superimposed on sickle cell nephropathy. We are stressing the importance of considering alternate disease processes in patients with SCD when symptoms change or when there is an atypical clinical course.