Open AccessLight chain nephropathy
Author(s) -
Sihem Darouich,
I. Bettaieb,
R. Aouadia,
H. Hedri,
E. Abderrahim,
R. Goucha,
A. Khedher
Publication year - 2015
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.157296
Subject(s) - medicine , immunoglobulin light chain , biopsy , nephropathy , pathology , isotype , dermatology , antibody , immunology , endocrinology , monoclonal antibody , diabetes mellitus
Light chain deposition disease (LCDD) is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype. It is the archetypal systemic disease that is most frequently diagnosed on a kidney biopsy, although the deposits may involve several other organs. This brief review focuses on the clinicopathological features of LCDD-associated nephropathy with an emphasis on the diagnostic and therapeutic difficulties related to this elusive condition.