Open AccessMetformin-associated lactic acidosis in a peritoneal dialysis patient
Author(s) -
Najlaa Almaleki,
Mohammad Javad Ashraf,
Majdi M Hussein,
Syed Atif Mohiuddin
Publication year - 2015
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.152498
Subject(s) - medicine , metformin , lactic acidosis , peritoneal dialysis , acidosis , hemodialysis , diabetes mellitus , dialysis , type 2 diabetes , gastroenterology , intensive care medicine , insulin , endocrinology
Metformin is one of the commonly used drugs in type-2 diabetes mellitus. It reduces glucose levels by increasing insulin sensitivity, reducing hepatic glucose release and increasing muscle uptake. One of the serious complications associated with metformin use is lactic acidosis, and it is associated with high morbidity and mortality. This is more likely to happen in patients with renal failure due to reduced clearance. International guidelines recommend discontinuing metformin in advanced renal failure. We report a case of metformin-associated lactic acidosis in a patient with end-stage renal disease on peritoneal dialysis. The patient presented with severe lactic acidosis, which was successfully treated with hemodialysis.