Open AccessAmyloidosis in Behcet′s disease
Author(s) -
I. Ben Ghorbel,
Nabil Belfeki,
T. Ben Salem,
M. Lamloum,
M.H. Houman
Publication year - 2015
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.148761
Subject(s) - medicine , amyloidosis , vasculitis , aa amyloidosis , behcet's disease , disease , nephrotic syndrome , dermatology , inflammation , refractory (planetary science) , immunology , gastroenterology , pathology , familial mediterranean fever , physics , astrobiology
Behcet's disease (BD) is a multisystem vasculitis with protean manifestations. It is characterized by a heightened state of inflammation, although the factors that initiate and sustain this inflammation are not clear. We report some cases of BD-associated amyloidosis and have similar features. The patients developed nephrotic syndrome due to secondary amyloidosis, which was refractory to the immunosuppressive agents. Two patients expired and the third was lost to follow-up during the course. The BD complicated with amyloidosis is associated with high mortality despite the current aggressive therapy.