Open AccessMetformin-related acidosis in a woman while performing Haj: A conservative approach
Author(s) -
Riyazuddin S. Ansari,
Ahmed Mady,
Hatem Qutub,
Eidah Althomaly,
Zainab Abdulaziz Alzayer,
Amna A. R. Moulana
Publication year - 2015
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.148759
Subject(s) - metformin , lactic acidosis , medicine , metabolic acidosis , acidosis , endocrinology , insulin resistance , diabetes mellitus , insulin , gastroenterology
Metformin is a first-line oral anti-hyperglycemic agent. It decreases insulin resistance, decreases hepatic glucose output and enhances peripheral glucose uptake. Metformin is used as a monotherapy in combination with other oral hypoglycemic agents. A major side-effect of metformin is lactic acidosis. The elimination of metformin is mainly through the kidneys, and raised plasma concentrations can cause lactic acidosis. Provided there is no overdose, metformin associated lactic acidosis rarely develops in patients without co-morbidities such as renal or hepatic insufficiency, acute infection or severe dehydration. Herein, we report a case of metformin-induced metabolic acidosis occurring in a woman who was severely dehydrated after performing Haj and treated conservatively.