Open AccessChronic graft versus host disease and nephrotic syndrome
Author(s) -
S. Barbouch,
H. Gaied,
K. Ben Abdelghani,
Rim Goucha,
Amel Lakhal,
Lamia Torjemen,
Fethi Ben Hamida,
E. Abderrahim,
H. Ben Maı̈z,
HafedhHedri,
A. Khedher
Publication year - 2014
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.139941
Subject(s) - medicine , nephrotic syndrome , glomerulonephritis , focal segmental glomerulosclerosis , renal biopsy , complication , biopsy , kidney disease , transplantation , bone marrow , bone marrow transplantation , minimal change disease , immunosuppression , graft versus host disease , pathology , kidney , gastroenterology
Disturbed kidney function is a common complication after bone marrow transplantation. Recently, attention has been given to immune-mediated glomerular damage related to graft versus host disease (GVHD). We describe a 19-year-old woman who developed membranous glomerulonephritis after bone marrow transplantation (BMT). Six months later, she developed soft palate, skin and liver lesions considered to be chronic GVHD. Fifteen months after undergoing BMT, this patient presented with nephrotic syndrome. A renal biopsy showed membranous glomerulonephritis associated with a focal segmental glomerulosclerosis. She was started on corticosteroid treatment with good outcome.