Open AccessLow-dose corticosteroid and gallium-67 scintigraphy and acute interstitial nephritis
Author(s) -
Tetsu Akimoto,
Ryoko Horikoshi,
Shigeaki Muto,
Eiji Kusano
Publication year - 2014
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.135184
Subject(s) - medicine , prednisolone , scintigraphy , nephritis , renal function , interstitial nephritis , diclofenac sodium , corticosteroid , diclofenac , drug , gastroenterology , urology , pathology , pharmacology , kidney
We describe a 19-year-old male who developed diclofenac-induced acute interstitial nephritis (AIN). Diffuse mononuclear cell infiltration was confirmed by renal biopsy and a Gallium (Ga)-67 scintigraphy revealed diffuse uptake of the isotope in both kidneys. His renal function had gradually and promptly recovered after initiation of low-dose prednisolone (0.5 mg/kg/day). There are no established criteria for the administration of corticosteroids in the treatment of drug-induced AIN. Moreover, no clear recommendations regarding the optimal dose and duration of steroid administration in the treatment for drug-induced AIN has been established. In addition, we discuss the clinical benefit of steroid treatment and the diagnostic impact of Ga scanning on the management of drug-induced AIN.