Open AccessANCA-mediated crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane
Author(s) -
Wiroon Sangsiraprapha,
Luan D. Truong,
Sreedhar Mandayam
Publication year - 2014
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.132221
Subject(s) - medicine , basement membrane , rapidly progressive glomerulonephritis , glomerular basement membrane , antibody , serology , glomerulonephritis , pathology , renal biopsy , anti neutrophil cytoplasmic antibody , immunoglobulin g , staining , kidney , immunology , biopsy , vasculitis , disease
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides is an important cause of rapidly progressive glomerulonephritides (RPGN), and they are classically described as pauci-immune diseases as evidenced by the absence of immune deposits on immunofluoresence microscopy of the kidney biopsy. We report two patients with RPGN, pulmonary-renal syndrome, positive ANCA serology and linear Immunoglobulin G (IgG) staining on glomerular basement membrane in the absence of detectable anti-glomerular basement membrane (anti-GBM) antibodies in the serum.