Open AccessPiperazine side-effects in a patient with pre-existing renal insufficiency
Author(s) -
Majid Malaki
Publication year - 2014
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.128573
Subject(s) - medicine , proteinuria , acute kidney injury , anemia , oliguria , nephrology , interstitial nephritis , pyuria , side effect (computer science) , adverse effect , gastroenterology , coma (optics) , kidney , pediatrics , renal function , urinary system , physics , optics , computer science , programming language
Piperazine as an antihelminth has many adverse effects, especially on patients with renal insufficiency. We report the use of piperazine in a girl with a moderately severe kidney disease due to Biedl Bardet syndrome. She developed coma and acute kidney injury due to acute interstitial nephritis (AIN), anemia and thrombocytopenia. The presence of fever, proteinuria, acidosis, anemia, sterile pyuria and non-oliguric renal failure strongly suggested AIN. Her problems abated mostly by discontinuing of piperazine and supportive therapy, except anemia and thrombocytopenia.