Open AccessPredictors of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism
Author(s) -
M. Hamouda,
N. Ben Dhia,
S. Aloui,
S El Mhamedi,
H. Skhiri,
M. Elmay
Publication year - 2013
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.121273
Subject(s) - medicine , parathyroidectomy , odds ratio , secondary hyperparathyroidism , hyperparathyroidism , gastroenterology , logistic regression , alkaline phosphatase , albumin , thyroidectomy , calcium , endocrinology , urology , surgery , parathyroid hormone , thyroid , biochemistry , chemistry , enzyme
We sought to identify predictors of development of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism. The patients were divided into two groups according to their serum calcium (Ca) levels within 24 hours of undergoing para-thyroidectomy: the hypocalcemia group (22 patients) with post-operative serum Ca levels of 2 mmol/L or less, and the normocalcemia group (48 patients), with post-operative serum Ca levels higher than 2 mmol/L. By using multivariate stepwise logistic regression analysis, high pre-operative serum Ca level had the strongest predictive value of development of early hypocalcemia with an adjusted odds ratio (aOR) of 3.01, followed by hypo-albuminemia (aOR = 2.72), younger age (aOR = 2.56), and high pre-operative alkaline phosphatase (ALP) levels (aOR = 2.28). We conclude that among patients with secondary hyperparathyroidism, age, levels of pre-operative serum Ca, ALP and albumin correlate positively with the development of early post-operative hypocalcemia. Patients with one of these factors should be monitored more closely in the early post-parathyroidectomy period.