Open AccessCombined liver and kidney transplantation in primary hyperoxaluria: A report of three cases and review of the literature
Author(s) -
Prasad Nair,
Torki Al-Otaibi,
Narayanan Nampoory,
Wafa’a Al-Qabandi,
Tarek Said,
M.A. Halim,
Osama Gheith
Publication year - 2013
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.118106
Subject(s) - primary hyperoxaluria , nephrocalcinosis , medicine , calcium oxalate , calcium oxalate crystals , liver transplantation , oxalate , kidney , transplantation , urology , kidney transplantation , kidney stones , gastroenterology , metabolic disorder , calcium , chemistry , organic chemistry
Primary hyperoxaluria type-1 (PH-1) is a rare autosomal recessive metabolic disorder leading to excessive oxalate production, deposition of calcium oxalate crystals in the kidney, nephrocalcinosis, progressive renal failure and systemic deposition of oxalate (oxalosis). Combined liver and kidney transplantation (LKT), which has been accepted as the treatment of choice for PH-1, has considerably improved patient and graft survival. Herein, we report our experience of three children with PH-1 who underwent combined LKT, with a review of the literature.