Open AccessLooking for the early marker of renal injury
Author(s) -
Ahmed S.A. Zaky
Publication year - 2015
Publication title -
the egyptian journal of internal medicine/the egyptian journal of internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2090-9098
pISSN - 1110-7782
DOI - 10.4103/1110-7782.159446
Subject(s) - medicine , biomarker , acute kidney injury , renal injury , urinary system , kidney , pathology , bioinformatics , biology , biochemistry
Acute Kidney Injury is a complex and increasingly common syndrome. Practically all available markers reflect functional impairment rather than a true direct mark of cellular injury. An ideal AKI biomarker should be accurate, reliable, easy to measure with a standard assay, noninvasive, reproducible, and sensitive and specific with defined cutoff values. Studies have identified a relatively small number of genes that are specifically altered in acute renal tubular injury. Kim-1 is one of the best-characterized urinary biomarkers to date in both experimental animals and humans with renal disease. Also NGAL is at the top of many researchers′ lists. Other biomarkers include IL-18, N-acetyl-β-d-glucosaminidase, and urinary liver-type fatty acid binding protein