Open AccessRole of abnormal Langerhans cells in oral epithelial dysplasia and oral squamous cell carcinoma: A pilot study
Author(s) -
Shyamsundar Vidya Rani,
Babu Aravindha,
S. Leena Sankari,
N Balachander,
L. Malathi,
Mahaboob Kadar Masthan
Publication year - 2015
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.166120
Subject(s) - epithelial dysplasia , pathology , dysplasia , medicine , carcinoma , immunohistochemistry , malignant transformation , inflammation , basal cell , immunology
The oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), although initiated by tobacco carcinogens, their progression is due to inability of Langerhans cells (LCs) to detect these abnormal cells and promote lymphocytes to destroy these cells. We assessed and quantified the tumor associated LCs and inflammation in OED and OSCC to understand their role.