Open AccessA rare case of clear cell variant of oral squamous cell carcinoma
Author(s) -
Sriram Kaliamoorthy,
Vijayparthiban Sethuraman,
Sathish Muthukumar Ramalingam,
S. Arunkumar
Publication year - 2015
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.149209
Subject(s) - cytokeratin , pathology , vimentin , immunohistochemistry , cytoplasm , connective tissue , cell , histopathology , antibody , tongue , periodic acid–schiff stain , biology , basal cell , clear cell , medicine , immunology , microbiology and biotechnology , genetics
Oral squamous cell carcinoma with prominent clear cell differentiation is a rare occurrence. A 35-year-old female patient presented with a nonhealing ulcer persistent for 1-month involving the left lateral border of the tongue and lingual vestibule. Lobules of malignant squamous epithelial cells with abundant cytoplasm and vesicular nuclei in the connective tissue were observed following histopathology. Neoplastic cells constituting majority of lobules exhibited clear cell changes. Periodic acid-Schiff and mucicarmine stains showed negative reaction. Immunohistochemical study using antibody for cytokeratin, revealed diffuse and intense positivity. The neoplastic cells showed complete negative reaction with antibodies for vimentin, smooth muscle actin and homatropine bromide-45 antigens.