Open AccessNodular sclerosing Hodgkin′s lymphoma with breast involvement: Case report and review of the literature
Author(s) -
Yashpal Modi,
David B. Thomas,
Hamid Shaaban,
Trevor Layne,
Gunwant Guron
Publication year - 2014
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.136258
Subject(s) - medicine , lymphoma , histopathology , fluorodeoxyglucose , biopsy , left breast , radiology , presentation (obstetrics) , positron emission tomography , breast ultrasound , breast cancer , pathology , mammography , cancer
Extranodal disease in Hodgkin's lymphoma (HL) is very rare and it occurs in 15-30% of all cases. The intrathoracic area is the most common extranodal presentation. There are very few cases in the medical literature of breast involvement with HL. We report a 25-year-old woman who had been managed and treated for nodular sclerosing HL for 6 months, but she was noncompliant with chemotherapy. She presented 1 year later with a palpable left breast mass and B symptoms. The fluorine-18 fluorodeoxyglucose-positron emission tomography images revealed disseminated disease with a left breast mass demonstrating fluorodeoxyglucose uptake. Histopathology of the ultrasound-guided biopsy specimen of the breast mass was consistent with recurrence. This case highlights the need for an awareness of HL presenting in this way because the diagnosis has therapeutic and prognostic implications.