Open AccessDocking studies for screening anticancer compounds of Azadirachta indica using Saccharomyces cerevisiae as model system
Author(s) -
M Krishnamoorthy,
Reena Balakrishnan
Publication year - 2014
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.127298
Subject(s) - azadirachta , cyclin dependent kinase , docking (animal) , cyclin dependent kinase 1 , cell cycle , cancer cell , biochemistry , biology , cdk inhibitor , cancer , chemistry , pharmacology , cell , botany , medicine , genetics , nursing
Plants have a long history of use in the treatment of cancer. Plant-derived compounds have played an important role in the development of several clinically useful anticancer agents. In the recent years, more emphasis has been placed on identifying plant-derived compounds that can be used as an effective treatment for life-threatening diseases such as cancer. Cancer is a disease where there is abnormal cell proliferation. The proliferation of the cancer cells are restrained by cdk/cyclin complexes, which control the normal process of cell cycle.