Open AccessProtective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats
Author(s) -
Banothu Anil Kumar,
A Gopala Reddy,
P Ravi Kumar,
Y. Ramana Reddy,
Thirtham Madava Rao,
C Haritha
Publication year - 2013
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.117021
Subject(s) - cadmium , toxicity , tbars , histopathology , chemistry , oxidative stress , sperm , cadmium chloride , reproductive toxicity , lead acetate , glutathione , metallothionein , andrology , zinc , pharmacology , lipid peroxidation , endocrinology , toxicology , medicine , biology , biochemistry , pathology , enzyme , organic chemistry
One of the target organs of heavy metals is testis and many authors proposed that oxidative stress could be responsible to induce their toxicity. An experimental study was conducted to evaluate the molecular mechanisms of lead (Pb) and cadmium (Cd) toxicity, their toxicodynamic interaction and to evaluate therapeutic potential of N-Acetyl L-cysteine (NAC) against the reproductive toxicity in male Wistar rats.