Open AccessPolymerase chain reaction and deoxyribonucleic acid-sequencing based study on distribution of human papillomavirus 16/18 among histopathological types of cervical intra-epithelial neoplasia and primary invasive cervical carcinoma: A scenario in North Bengal, India
Author(s) -
Pranab Ghosh,
Damayanti Das Ghosh,
Amita Majumdar,
Shamik Sengupta,
Chandana Das,
Indranil Mukhopadhyay
Publication year - 2014
Publication title -
journal of mid-life health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.423
H-Index - 11
eISSN - 0976-7819
pISSN - 0976-7800
DOI - 10.4103/0976-7800.127786
Subject(s) - adenocarcinoma , genotyping , polymerase chain reaction , genotype , exact test , cervical cancer , pathology , biology , carcinoma , medicine , cancer , oncology , gene , genetics
Human papillomavirus (HPV) types 16/18 are reportedly most common in cervical cancer (CaCx) with geographical variation of genotypes. HPV16 predominates both in squamous cell carcinoma (SCC) and adenocarcinoma in India, contrary to reported global predominance of HPV18 in the latter. Our study was aimed to determine the occurrence of HPV16/18 among histopathological types of cervical intra-epithelial neoplasia (CIN) and invasive CaCx from North Bengal, India and to identify any major deviation from the known Indian scenario of distribution of HPV16/18 genotypes in cases of SCC and adenocarcinoma.