Open AccessFixed drug eruption due to levocetirizine
Author(s) -
Ratinder Jhaj,
Dinesh P Asati,
Deepa Chaudhary
Publication year - 2016
Publication title -
journal of pharmacology and pharmacotherapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.301
H-Index - 34
eISSN - 0976-5018
pISSN - 0976-500X
DOI - 10.4103/0976-500x.184778
Subject(s) - cetirizine , levocetirizine , antihistamine , medicine , drug eruption , histamine , dermatology , histamine h1 receptor , drug , adverse drug reaction , adverse effect , allergic reaction , pharmacology , drug reaction , allergy , immunology , receptor , antagonist
A fixed drug eruption (FDE) is a cutaneous adverse drug reaction due to Type IV or delayed cell-mediated hypersensitivity. Antihistamines, which antagonize the action of histamine during an allergic reaction by blocking the H1 histamine receptors, are used routinely for the treatment of various allergic disorders such as urticaria, eczemas, and also in itchy lesions of skin like scabies. Levocetirizine, an active (R)-enantiomer of cetirizine, is a newer or second generation antihistamine, with more specific actions and fewer side effects, including cutaneous reactions. FDE due to levocetirizine as well as with cetirizine are rare. We report a case of levocetirizine induced FDE in a 49-year-old male patient with scabies. The patient had a history of cetirizine induced FDE in the past.