Open AccessLife-threatening bradyarrhythmia with oral phenytoin overdose
Author(s) -
Giridharan Srinivasan,
Mukta Wyawahare,
Pratheesh George Mathen,
D. K. S. Subrahmanyam
Publication year - 2015
Publication title -
journal of pharmacology and pharmacotherapeutics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.301
H-Index - 34
eISSN - 0976-5018
pISSN - 0976-500X
DOI - 10.4103/0976-500x.162017
Subject(s) - phenytoin , bradycardia , medicine , cardiotoxicity , anesthesia , inotrope , sinus bradycardia , glibenclamide , toxicity , cardiology , heart rate , epilepsy , diabetes mellitus , blood pressure , endocrinology , psychiatry
We report a case of a 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer for her hemodynamic instability. This life-threatening cardiotoxicity of phenytoin could have been due to its interaction with sulphonylurea. It is imperative to be aware of drug interactions, due to which, life-threatening cardiovascular manifestations following phenytoin toxicity can occur.