Open AccessLeukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure
Author(s) -
Sachin Agrawal,
Atulsingh Rajput,
Alok Pal Jain
Publication year - 2014
Publication title -
journal of pharmacology and pharmacotherapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.301
H-Index - 34
eISSN - 0976-5018
pISSN - 0976-500X
DOI - 10.4103/0976-500x.142453
Subject(s) - medicine , palpable purpura , ceftriaxone , vasculitis , interstitial nephritis , dermatology , skin biopsy , nephritis , leukocytoclastic vasculitis , purpura (gastropod) , antibiotics , lesion , pathology , biopsy , kidney , disease , henoch schonlein purpura , microbiology and biotechnology , biology , ecology
Leukocytoclastic vasculitis (LCV), also known as hypersensitivity vasculitis is a small vessel inflammatory disease which mainly involves the postcapillary venules. A 17-year-old girl developed palpable purpura over lower limbs and acute allergic interstitial nephritis 5 days after exposure to ceftriaxone. Skin biopsy from the lesion over lower limbs confirmed the diagnosis of LCV. Discontinuation of drug and treatment with steroid resulted in resolution of skin lesions and normalization of kidney functions. Beta-lactams are commonly used antibiotics in various types of infection in day-to-day practice. LCV, a rare complication of ceftriaxone should be kept in mind while using this drug.