Open AccessC-deletion in exon 4 codon 63 of p53 gene as a molecular marker for oral squamous cell carcinoma: A preliminary study
Author(s) -
H. S. Sukhija,
K Rajkumar,
N Balachander,
R Karthik,
Ramya Ramadoss,
Sukanta Sen
Publication year - 2015
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/0976-237x.166840
Subject(s) - exon , microbiology and biotechnology , agarose gel electrophoresis , saliva , polymerase chain reaction , gene , mutation , gene mutation , genomic dna , biology , basal cell , cancer research , genetics , medicine , pathology , biochemistry
Exfoliated oral cancer cells in saliva samples from patients with oral squamous cell carcinoma (OSCC) can be used to determine the incidence and type of mutations of the p53 tumor suppressor gene. The purpose of this study was to identify C-deletion mutation in exon 4 codon 63 of p53 gene in the saliva of OSCC patients by polymerase chain reaction (PCR).