Open AccessStudy of the association between the interleukin-1 β c.3954C>T polymorphism and periodontitis in a population sample from Bahia, Brazil
Author(s) -
Samir Andrade Mendonça,
Fernanda Gabriela Teixeira,
Kamilla Menezes Oliveira,
Djanilson Barbosa dos Santos,
Lucas Miranda Marques,
Maise Mendonça Amorim,
Raquel de Souza Gestinari
Publication year - 2015
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/0976-237x.156040
Subject(s) - periodontitis , genotyping , saliva , genotype , population , immunology , medicine , biology , gene , genetics , environmental health
Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. Different factors are associated with the onset and prognosis of this disease, both environmental and genetic. The latter particularly relate to molecules secreted as a function of the host immune response, such as pro-inflammatory cytokines. Studies indicate that the polymorphism c. 3954C > T in the interleukin-1 β encoding gene (IL1B) can be considered as an aggravating factor in the periodontitis condition.