Open AccessIdiopathic thrombocytopenic purpura
Author(s) -
L Kayal,
Jayachandran Sadaksharam,
Khushboo Singh
Publication year - 2014
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/0976-237x.137976
Subject(s) - medicine , thrombocytopenic purpura , thrombopoietin , platelet , purpura (gastropod) , presentation (obstetrics) , bone marrow , immune thrombocytopenia , splenectomy , bone marrow failure , gastroenterology , immunology , surgery , spleen , haematopoiesis , ecology , stem cell , biology , genetics
Idiopathic thrombocytopenic purpura (ITP) is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. The major causes of accelerated platelet consumption include immune thrombocytopenia, decreased bone marrow production, and increased splenic sequestration. The clinical presentation may be acute with severe bleeding, or insidious with slow development with mild or no symptoms. The initial laboratory tests useful at the first visit to predict future diagnosis were erythrocyte count, leukocyte count, anti-glycoprotein IIb/IIIa antibodies, reticulated platelets, plasma thrombopoietin level. Treatment should be restricted to those patients with moderate or severe thrombocytopenia who are bleeding or at risk of bleeding. We present a case report on ITP with clinical presentation, diagnosis and management.