Open AccessAdrenomedullin, periodontitis, diabetes-unraveling the equivocal relationship: A clinicobiochemical cross-sectional study
Author(s) -
A Suchetha,
Akanksha Garg,
Lakshmi Puzhankara,
Divya Bhat,
N Sapna,
S M Apoorva
Publication year - 2013
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/0976-237x.123040
Subject(s) - adrenomedullin , medicine , periodontitis , diabetes mellitus , bleeding on probing , type 2 diabetes , glycated hemoglobin , chronic periodontitis , gastroenterology , dentistry , endocrinology , receptor
Antimicrobial proteins and peptides constitute a diverse class of host-defense molecules that act early to combat invasion and infection with bacteria and other microorganisms. Among the various antimicrobial peptides in the oral cavity, adrenomedullin (ADM), a cationic peptide, is found in gingival crevicular fluids (GCFs) in amounts twice as high in periodontal disease sites as healthy sites. Studies have also shown that plasma levels of ADM increased in patients with type 2 diabetes mellitus as compared with controls.