Superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia, and oral cancer: A comparative study | Zendy

Yadavalli Guruprasad | Zendy; Shubha Gurudath | Zendy; RaghavendraMahadev Naik | Zendy; KS Ganapathy | Zendy; D Sujatha | Zendy; Anuradha Pai | Zendy

Open Access

Superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia, and oral cancer: A comparative study

Author(s) -

Yadavalli Guruprasad,

Shubha Gurudath,

RaghavendraMahadev Naik,

KS Ganapathy,

D Sujatha,

Anuradha Pai

Publication year - 2012

Publication title -

journal of orofacial sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.171

H-Index - 6

eISSN - 2320-4737

pISSN - 0975-8844

DOI - 10.4103/0975-8844.106202

Subject(s) - oral submucous fibrosis , medicine , leukoplakia , glutathione peroxidase , superoxide dismutase , cancer , gastroenterology , oral leukoplakia , biomarker , oxidative stress , biochemistry , biology

Objectives: Present study was undertaken to estimate and compare erythrocyte superoxide dismutase (E-SOD) and glutathione peroxidase (GPx) levels in oral submucous fibrosis, oral leukoplakia, oral cancer patients, and healthy subjects. Materials and Methods: E-SOD and GPx levels were estimated in OSF, oral leukoplakia, and oral cancer patients with 25 subjects in each group. The results obtained were compared with the corresponding age-/sex- matched control groups. Results: Statistically significant ( P < 0.001) decrease in E-SOD and GPx levels were observed in OSF, oral leukoplakia, and oral cancer groups as compared to the control group. Oral leukoplakia group showed lower levels in comparison with OSF ( P > 0.05). Oral cancer group had the lowest levels amongst the study groups. Conclusion: Imbalance in antioxidant enzyme status may be considered as one of the factors responsible for the pathogenesis of cancer and may serve as a potential biomarker and therapeutic target to reduce the malignant transformation in oral premalignant lesions/conditions

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