Open AccessThe effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats
Author(s) -
Mahmoud Hosseini,
Samaneh Zakeri,
Sadieh Khoshdast,
Fatemeh Yousefian,
Monireh Rastegar,
Farzaneh Vafaee,
Shamsi Kahdouee,
Fatemeh Ghorbani,
Hassan Rakhshandeh,
S Abolfazl Kazemi
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.99052
Subject(s) - thymoquinone , nigella sativa , behavioural despair test , lipopolysaccharide , pharmacology , saline , medicine , open field , intraperitoneal injection , traditional medicine , chemistry , antioxidant , anesthesia , hippocampus , antidepressant , biochemistry
Neuroimmune factors have been proposed as contributors to the pathogenesis of depression. Beside other therapeutic effects including neuroprotective, antioxidant, anticonvulsant and analgesic effects, Nigella sativa and its main ingredient, thymoquinone (TQ), have been shown to have anti-inflammatory effects. In the present study, the effects of Nigella sativa hydro-alcoholic extract and thymoquinone was investigated on lipopolysaccharide- induced depression like behavior in rats.