Open AccessNew evidence on α-synuclein and Tau binding to conformation and sequence specific GCFNx01 rich DNA: Relevance to neurological disorders
Author(s) -
Vasudevaraju Padmaraju,
Erika N. Guerrero,
Muralidhar L. Hegde,
TB Collen,
Gabrielle B. Britton,
K. S. Rao
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94811
Subject(s) - dna , dna sequencing , oligonucleotide , z dna , base pair , biology , hmg box , circular dichroism , chemistry , gene , microbiology and biotechnology , biochemistry , dna binding protein , transcription factor
Deoxyribonucleic acid (DNA) topology plays a critical role in maintaining the integrity of the genome and cellular functions. Although changes in DNA conformation and structural dynamics in the brain have been associated with various neurological disorders, its precise role in the pathogenesis is still unclear. Previous studies from our laboratory have shown that there is a conformational change in the genomic DNA of Parkinson's disease (PD) (B to altered B-DNA) and Alzheimer's disease brain (B to Z-DNA). However, there is limited information on the mechanism on DNA dynamics changes in brain.