Open AccessEffect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
Author(s) -
Shivam U Upadhyay,
J K Patel,
Viraat Patel,
A. K. Saluja
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94161
Subject(s) - solid lipid nanoparticle , zeta potential , dispersity , particle size , sonication , chemistry , tamoxifen , nanoparticle , chromatography , citric acid , chemical engineering , materials science , breast cancer , nanotechnology , biochemistry , organic chemistry , medicine , cancer , engineering
Tamoxifen Citrate (TC) is an estrogen receptor antagonist and drug of choice for hormone sensitive breast cancer. Solid Lipid Nanoparticles loaded with TC were prepared by High Shear Homogenization followed by Ultrasonication. The aim of the present work is to study the effect of four different Solid Lipids and three Surfactants on Formulation and Stability of SLN. They were characterized for Particle size, Polydispersity Index and Zeta Potential by Zetasizer Nano. SLN prepared by Solid Lipid Compritol 888 (Glyceryldibehenate) and Tween 80 (1%) showed desired Particle Size of 206.9 nm, PDI of 0.046 and Zeta Potential of 9.32 mV.