Open AccessFormulation and evalution of montelukast sodium - chitosan based spray dried microspheres for pulmonary drug delivery
Author(s) -
Rushi Panchal,
Harsha Patel,
Viraat Patel,
Pratik U. Joshi,
Ankit Parikh
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94160
Subject(s) - chitosan , mucoadhesion , particle size , glutaraldehyde , spray drying , materials science , microsphere , swelling , drug delivery , chemical engineering , chromatography , chemistry , drug carrier , nanotechnology , composite material , organic chemistry , engineering
The objective of present work was to prepare microspheres of montelukast sodium using a natural polymer- chitosan by spray drying method by using glutaraldehyde as a cross linking agent. The microspheres were characterized for size, shape, dissolution, swelling and mucoadhesion. It was observed that, all microspheres were spherical in shape with narrow size distribution. Microspheres had mean particle size of 7-12 μm, with % encapsulation efficiency of 78-86%. The % yield was 32-49% and drug load was 48-53%. With the increase in proportion of chitosan in formulation mucoadhesive strength was increase and also increased in particle size of microspheres. As the drug:polymer ratio increase drug loading was increase and % encapsulation efficiency was also increase.