Open AccessOptimization of fast disintegration tablets using pullulan as diluent by central composite experimental design
Author(s) -
Dipil Patel,
Musharraf Chauhan,
Ravi R. Patel,
Jayvadan Patel
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94150
Subject(s) - diluent , pullulan , central composite design , composite number , materials science , lactose , chromatography , response surface methodology , chemistry , composite material , polysaccharide , nuclear chemistry , organic chemistry
The objective of this work was to apply central composite experimental design to investigate main and interaction effect of formulation parameters in optimizing novel fast disintegration tablets formulation using pullulan as diluents. Face centered central composite experimental design was employed to optimize fast disintegration tablet formulation. The variables studied were concentration of diluents (pullulan, X(1)), superdisintigrant (sodium starch glycolate, X(2)), and direct compression aid (spray dried lactose, X(3)). Tablets were characterized for weight variation, thickness, disintegration time (Y(1)) and hardness (Y(2)). Good correlation between the predicted values and experimental data of the optimized formulation methodology in optimizing fast disintegrating tablets using pullulan as a diluent.