Open AccessEnhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach
Author(s) -
Dnyaneshwar M. Thakar,
Praful D. Bharadia,
Manish R Pandya
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94137
Subject(s) - poloxamer 407 , poloxamer , telmisartan , zeta potential , solubility , particle size , materials science , bioavailability , chromatography , drug , chemical engineering , polymer , chemistry , pharmacology , nanotechnology , nanoparticle , medicine , organic chemistry , composite material , blood pressure , engineering , copolymer , radiology
The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process. In this study, the practically water-insoluble telmisartan was nanoground by using top down method i.e. media milling method. Here the media used is ZnO(2) beads. A variety of surface active agents were tested for their stabilizing effects. Formulation factors evaluated were ratio of polymer to drug, whereas process parameters were milling time and concentration of ZnO(2) beads. Different concentration of stabilizers such as poloxamer 188, poloxamer 407, HPMC E 15, PVP K30 and combination of stabilizers were used for preparation of telmisartan nanosuspension. Responses measured in this study include particle size measurement, particle size distribution and zeta potential.