Open AccessFormulation and evaluation of bilayer tablet by using melt granulation technique for treatment of diabetes mellitus
Author(s) -
Dhruvita Patel,
Ankita Patel,
Trupti Solanki
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94135
Subject(s) - pioglitazone , granulation , metformin , bilayer , immediate release , pharmacology , factorial experiment , matrix (chemical analysis) , biomedical engineering , materials science , diabetes mellitus , medicine , chromatography , chemistry , mathematics , membrane , composite material , type 2 diabetes , endocrinology , biochemistry , statistics
The objective of present study was to prepare and characterize Bilayer tablet formulation containing Metformin HCl in extended release matrix form and Pioglitazone HCl in immediate release form for the treatment of diabetes mellitus. Different formulations containing Metformin HCl were manufactured using 3(2) factorial designs. Influence of hydrophilic carrier, hydrophobic polymer on drug release was studied. Immediate release layer of Pioglitazone was optimized using different super disintegrants. All formulations were evaluated for percentage drug release. Optimization results indicated that release rate of Metformin is directly proportional to the levels of Eudragit S 100 and PEG 6000. Results confirmed that Bilayer tablet formulation containing extended release of Metformin HCl and immediate release of Pioglitazone HCl could be developed by using melt granulation technique.