Open AccessMethod optimization of ocular patches
Author(s) -
Kamalesh Upreti,
Prashant Dabral,
Vinod Rana,
Kumud Upadhyaya,
Anjali Badhani
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94130
Subject(s) - gelatin , glutaraldehyde , polymer , petri dish , elasticity (physics) , solubility , materials science , solvent , chemical engineering , chemistry , polymer chemistry , polymer science , chromatography , composite material , organic chemistry , biology , engineering , genetics
The intraocular patches were prepared using gelatin as the polymer. Ocular patch were prepared by solvent casting method. The patches were prepared for six formulations GP1, GP2, GP3, GP4, GP5 and GP6. Petri dishes were used for formulation of ocular patch. Gelatin was used as a polymer of choice. Glutaraldehyde used as cross linking agent and (DMSO) dimethylsulfoxide used as solubility enhancer. The elasticity depends upon the concentration of gelatin. 400 mg amount of polymer i.e gelatin gave the required elasticity for the formulation.