Open AccessEffect of components (polymer, plasticizer and solvent) as a variable in fabrication of diclofenac transdermal patch
Author(s) -
Chetna Modi
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94129
Subject(s) - transdermal , plasticizer , transdermal patch , diclofenac , bioavailability , fabrication , solvent , polymer , chemistry , peg 400 , materials science , pharmacology , chemical engineering , organic chemistry , medicine , polyethylene glycol , alternative medicine , pathology , engineering
Transdermal drug delivery influence consumer acceptance and marked increase in bioavailability of some drugs which undergoes hepatic first-pass metabolism. Fabrication of transdermal patch requires lots of attention regarding the amount of components used for it. Because of varied nature of polymer and plasticizer, transdermal patches have different properties and different drug release. This study is on the basis to evaluate the amount to be needed for fabrication of diclofenac transdermal patch. Study shows that Hydroxy Propyl Methyl Cellulose has great influence on transdermal patch, if it is used alone in combination with glycerin or PEG-4000 plasticizer.