Open AccessEvaluation of cyclodextrins for enhancing corneal penetration of natamycin eye drops
Author(s) -
Anjali Badhani,
Prashant Dabral,
Vinod Rana,
Kumud Upadhyaya
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.94128
Subject(s) - natamycin , solubility , aqueous solution , cyclodextrin , eye drop , chromatography , chemistry , solubilization , antifungal , penetration (warfare) , drug , drop (telecommunication) , ophthalmology , organic chemistry , pharmacology , medicine , mathematics , computer science , food science , dermatology , biochemistry , telecommunications , operations research
A new group of pharmaceutical excipients called cyclodextrins can be introduced into ophthalmology for delivering such water insoluble drug. This group of excipients is able to solubilize many water insoluble drugs which were previously impossible to be formulated as aqueous eye drop solution by forming their inclusion complexes. Analysis of pure drug and excipients by physical test, melting point determination, chemical test and solubility determination were carried out in this study. It may be concluded that cyclodextrin complexes of Natamycin can lead to an aqueous formulation (Natamycin eye drop) having better trans corneal permeability and thus can be proved to have faster and better antifungal efficiency.