Open AccessFormulation and characterization of lipid-based drug delivery system of raloxifene-microemulsion and self-microemulsifying drug delivery system
Author(s) -
Hetal Thakkar,
Jitesh Nangesh,
Mayur Prakashbhai Parmar,
Divyakant Patel
Publication year - 2011
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.84463
Subject(s) - bioavailability , raloxifene , microemulsion , pharmacology , zeta potential , drug delivery , first pass effect , drug , permeation , pharmacokinetics , chemistry , selective estrogen receptor modulator , medicine , materials science , estrogen receptor , nanotechnology , membrane , nanoparticle , biochemistry , pulmonary surfactant , organic chemistry , breast cancer , cancer
Raloxifene, a second-generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women is administered orally in the form of a tablet. The absolute bioavailability of the drug is only 2% because of extensive hepatic first-pass metabolism. Lipid-based formulations are reported to reduce the first-pass metabolism by promoting its lymphatic uptake.