Open AccessExperimental re-evaluation of flunarizine as add-on antiepileptic therapy
Author(s) -
Ashwani Kumar Thakur,
Amit Sahai,
JS Thakur
Publication year - 2011
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.80782
Subject(s) - flunarizine , anticonvulsant , lamotrigine , medicine , pharmacology , valproic acid , epilepsy , calcium channel , carbamazepine , anesthesia , analysis of variance , calcium , psychiatry
Experimental studies have found several calcium channel blockers with anticonvulsant property. Flunarizine is one of the most potent calcium channel blockers, which has shown anticonvulsant effect against pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures. However, further experimental and clinical trials have shown varied results. We conducted a PTZ model experimental study to re-evaluate the potential of flunarizine for add-on therapy in the management of refractory epilepsy.