Open AccessPeptide IC-20, encoded by skin kininogen-1 of the European yellow-bellied toad, Bombina variegata, antagonizes bradykinin-induced arterial smooth muscle relaxation
Author(s) -
Miao Yang,
Mei Zhou,
Bing Bai,
Chengbang Ma,
Wei Lin,
Lei Wang,
Christopher Shaw
Publication year - 2011
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.80774
Subject(s) - peptide , bradykinin , biochemistry , peptide sequence , frog skin , chemistry , kininogen , microbiology and biotechnology , biology , receptor , organic chemistry , gene , sodium
The objectives were to determine if the skin secretion of the European yellow-bellied toad (Bombina variegata), in common with other related species, contains a bradykinin inhibitor peptide and to isolate and structurally characterize this peptide.