Open AccessPolymeric ocular hydrogels and ophthalmic inserts for controlled release of timolol maleate
Author(s) -
Vinod Kumar Singh,
SS Bushetti,
S. Appala Raju,
Rizwan Ahmad,
Mamta Singh,
Mohammad Ajmal
Publication year - 2011
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.80773
Subject(s) - self healing hydrogels , bioavailability , timolol , chemistry , drug delivery , viscometer , drug , pharmacology , biomedical engineering , viscosity , chromatography , materials science , ophthalmology , medicine , organic chemistry , composite material , intraocular pressure
Ophthalmic drug delivery systems are the challenging subject for the researchers because of delicate nature of ocular membrane and preventive barriers leading to less than 1 % of Bioavailability. Reasons for reduced bioavailability are due to rapid pre corneal elimination, tear turnover, lacrimal drainage, blinking and degradation by enzymes. Less bioavailability causes short duration of action and increased frequency of administration.