Open AccessAntidepressant potential of nitrogen-containing heterocyclic moieties: An updated review
Author(s) -
Nadeem Siddiqui,
Andalip,
Sandhya Bawa,
Rahmat Ali,
Obaid Afzal,
Mohd Akhtar,
Bishmillah Azad,
Rajiv Kumar
Publication year - 2011
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.80765
Subject(s) - antidepressant , psychiatry , depression (economics) , panic disorder , anxiety , mood , medical prescription , medicine , mood disorders , psychology , pharmacology , economics , macroeconomics
Depression is currently the fourth leading cause of disease or disability worldwide. Antidepressant is approved for the treatment of major depression (including paediatric depression), obsessive-compulsive disorder (in both adult and paediatric populations), bulimia nervosa, panic disorder and premenstrual dysphoric disorder. Antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia and anxiety disorders such as social anxiety disorder. Many drugs produce an antidepressant effect, but restrictions on their use have caused controversy and off-label prescription a risk, despite claims of superior efficacy. Our current understanding of its pathogenesis is limited and existing treatments are inadequate, providing relief to only a subset of people suffering from depression. Reviews of literature suggest that heterocyclic moieties and their derivatives has proven success in treating depression.